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未来药物治疗

药物基因组学：未来药物治疗？

药物治疗仍然是医学支柱（这个直接引证FIX)。在某些情景中，一个药物可能有威胁生命的副作用，病人可能对这个药物本身有不良反应，或者在可怕的情况，一个病人的生命处于危险之中，这个药物出乎意料的没有作用。这些情景就是原为什么药物基因组学要被成立，现在对病因论的机理提供深刻的理解。

一个案例研究表示：

一个年轻的孕妇经历了一个切面的手术，被给予通常在麻醉感应中担当一个肌肉松弛剂的琥珀胆碱，在这个过程之后，她瘫痪了6个小时，达到有必要给她一个口罩来辅助通气。血液检查透露她遭受了假胆碱酯酶的缺乏。（法根隆德，布拉登2001）
我们的案例研究展示了每一个人有一个不同的基因组成，一体适用，杰西J斯文以及其他人（2007）对药物和剂量的态度不是一直满足的。
临床的药物基因组学保证这个想法关于个人药物结果减少了不利药物的反应，增加了药物处方的安全性和功效。一个最近的研究（赫斯，库伯1999）表明大量可变药物的反应性是由基因组突变造成的，被称为多态性。
最普通的突变成为遗传变异的原因，被称为是单一的核甘酸多态性(SNPs)，这里有一个单一的转换在核甘酸酸碱，代替物，删除和插入，表明这些多形体在所有个体间的变异应负责90%。

The future of drug therapy

药物基因组学：未来药物治疗？-Pharmacogenomics: The future of drug therapy?

Drug treatment remains the Mainstay of medicine (this is quoted directly FIX). In certain situations a drug may have life threatening side effects where the patient may have an adverse reaction to the drug itself, or in dire cases where a patient's life is at stake and the drug unexpectedly has no effect. These situations are the reasons to why Pharmacogenomics was established and now offers insight into the aetiological mechanisms.

一个案例研究表示-A case study showed:

“A young pregnant women who underwent a sectio caesariae was given suxomethonium which normally acts as a muscle relaxant n the induction of anaesthesia, she was paralysed for 6 hours after the procedure, making it necessary to give her assisted ventilation by respirator. Blood tests revealed that she suffered from pseudocholinesterase (buturycholinesterase) deficiency” (Fagerlund and Braaten 2001).
Our case study exhibits that every person has a different genetic make-up and that The “one size fits all” Jesse J.swen et al. (2007) attitude towards drugs and dosages does not always suffice.
Clinical Pharmacogenomics assures this idea of personalised medicine consequently decreasing adverse drug reactions and increasing the safety and efficacy of drug prescription. A recent study (Hess and Cooper 1999) indicated that most variable drug responsiveness is caused by mutations in the genome known as polymorphisms.
The most common mutations found causing genetic variation are known as single nucleotide polymorphisms (SNPs) where there's a single switch in the nucleotide bases; substitution, deletion or insertion. A recent study (SL et al. 2000) indicated that these polymorphisms are to be accountable for 90% of all inter-individual variation. A polymorphic gene can have tragic consequences for a person as a change in the nucleotide sequence of a gene alters the mRNA strand which transfers the DNA sequence for the coding of an amino acid and if the correct amino acid is not produced it ultimately leads to the wrong protein being produced. This variation can therefore affect drug safety and efficacy if a protein that is normally a drug target or involved in the drug transport is altered.(Veenstra and Higashi 2000).
Metabolising enzymes are another cause to explore as variations in these genes can result in array of different phenotypes. One important family of enzyme metabolisers are the “cytochrome P450” and account for most of phase 1 metabolism of drugs, in studying this family it gives an insight into some of the causes of adverse drug reactions and steps to take in order to prevent thes本论文由英语论文网提供整理，提供论文代写，英语论文代写，代写论文，代写英语论文，代写留学生论文，代写英文论文，留学生论文代写相关核心关键词搜索。