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论文作者:留学生论文论文属性:短文 essay登出时间:2010-06-15编辑:vshellyn点击率:4294
论文字数:论文编号:org201006152005559723语种:英语 English地区:泰国价格:免费论文
of the cells that it gets into, thereby giving it a high toxicity level.
The formula for AZT is C H N O . The molar mass of AZT is 267.24 grams
per mole. AZT's melting point is between 106 C and 112 C. AZT is soluble in water,
which is important so that it may dissolve into the human blood and be distributed to
the cells. AZT is usually taken in a pill format, but it is absorbed by the skin, which can
make it dangerous for people handling the drug.
There is quite a bit of controversy about the effectiveness of AZT. Most
experts agree that AZT delays the progression of HIV disease; the drug may also
prolong the disease-free survival period. However, many doctors still disagree with
using AZT as a treatment for AIDS. Peter Duesberg, a professor of molecular biology
at the university of California, Berkley, says that "In view of this, [the cytotoxicity
level of AZT] there is no rational explanation of how AZT could be beneficial to AIDS
patients, even if HIV were proven to cause AIDS." This comment stems from the fact
that AZT has a very high cytotoxicity level, which means that while it kills the infected
cells, it will also kill perfectly healthy cells. According to Dr. Duesberg, AZT will kill
approximately nine hundred and ninety nine healthy cells for each infected cell that it
kills. Most of this opposition to AZT stems from the fact that the initial testing for the
drug had severe problems associated with it. These initial tests were performed with
two groups of AIDS patients. The volunteering patients were secretly divided into two
groups using a double-blind system, where neither the patients nor the doctors are
aware of who is in the placebo, or control group, and who is in the AZT group. These
tests were performed by the FDA at twelve medical centers throughout the United
States. The study actually became unblinded almost immediately as some patients
discovered a difference in taste between the placebo and AZT caplets and other
patients took the capsules to chemists to have them analyzed. The doctors found out
the differences between AZT patients and the placebo patients by very obvious
differences in blood profiles. An FDA meeting was convened and the decision was
made to keep all of the useless data, and therefore the bad data was thrown in with the
good data and it ended up making all of the data virtually useless. In fact, according to
some sources, AZT ended up shortening the lifespans of many of the patients taking it.
AZT is also thought to be a possible carcinogen, although it has not been around long
enough for any conclusive results to be obtained. After AZT was approved for use,
mortality statistics were taken, they showed a mortality rate of 10% after 17 weeks,
with the original number of patients being 4805. The FDA tests, with their skewed
statistics, showed only a 1% mortality rate. AZT also had some strange side-effects
that were reported with it's use, such as raising the IQs of 21 children who took the
drug by 15 points, 5 of the children died.
The newest treatments with AZT are combining AZT with other drugs, such as
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