英语论文网

连续流动在有机/药物合成中的应用
The application of continuous flow in organic/drug synthesis

连续流动化学是近十年来发展起来的一种新的和潜在的技术。该技术的优良性能是它的高安全性能和显著的传热和传质速度，全过程可以通过自动程序实现，在线实时监控。因此，连续流动技术提供了更好的改进方式和反应广泛应用于有机合成和药物。本试验的目的是在连续流动技术原理进行综合概述和评价其优劣的连续流动过程。同时还介绍了该技术在有机药物合成化学中的各种应用。合成化学的未来可能依赖于连续流动技术的发展。

Abstract 摘要
Continuous flow chemistry is a new andmost potential technology developed in the recent ten years. The outstanding properties of this technology are its high safety performance and remarkably speed of heat and mass transmission.The whole process can be achieved by automatic programs and monitored on line real-time. Thus, the continuous flow technology offers animproved way to perform better reactions and widely apply in organic and drug synthesis. The aim of this assay is to give acomprehensive overview on the principlesof continuous flow technology and evaluate its pros and cons of the continuous flow processes. And the assay also introduce the various applications of this technology in the organic drug synthetic chemistry recently. The future of synthetic chemistry might rely on the development of continuous flow technology.

TEXT
Effective synthetic chemistry is very important for the pharmaceutical industry. The previousindustrial processes such as organic molecular’ production are mostly carried out in batch reactors. However, the chemical production in batch reactors are not selectivity, safety and manageable. The pharmaceutical industry has been adapting to change its approaches and strategies in the past few years that it can improve better solutions for effective drug synthesis.In the recent ten years, the continuous flow synthesis is emerging as one of the most potential techniques to significantly improve and impact on the pharmaceutical processes1.
As we all know, the continuous flow synthesis is a technology used to manufacture, produce and process materials without interruption. The materials for the processes, such as gas, liquid or solid, is delivered in the micro channel to the micro reactors through the stress of pumps. The whole synthesis processes can operate automatically and controlled by computer programs. This technology is initially used to apply for the common industrial production, such as petrochemicals and gases. Compared with the traditional batch reactor, the continuous flow reactor has more advantages. In the following section, I will explain the principles and characters of continuous flow synthesis briefly2.
The continuous flow chemical device is mainly composed of a micro reactor and a pump, which could be a high performance liquid chromatography (HPLC) pump, a peristaltic pump or a syringe pump3.
In the simplest form, the micro reactors consist of a network of micronsized or sub-micron sized channels (normally 10 to 300 μm in diameter)etched into materials. The volume of the micro reactors can be varied by the length and diameter of the channels. And according to the channel diameter, the device can be divided into small (50 to 1000 μm in diameter, <100 g in production), middle (1 to 10 nm in diameter, 10 to 100 kg in production) or large (50 to 1000 μm in diameter, >1000 kg in production) scales and obtain different number of productions3. The micro reactors can be constructed by plenty of materials, such as silicon, glass, metals, quartz and polymers. Considering of th