留学生硕士论文 英国论文 日语论文 澳洲论文 Turnitin剽窃检测 英语论文发表 留学中国 欧美文学特区 论文寄售中心 论文翻译中心 我要定制

Bussiness ManagementMBAstrategyHuman ResourceMarketingHospitalityE-commerceInternational Tradingproject managementmedia managementLogisticsFinanceAccountingadvertisingLawBusiness LawEducationEconomicsBusiness Reportbusiness planresearch proposal


ResumeRecommendation LetterMotivation LetterPSapplication letterMBA essayBusiness Letteradmission letter Offer letter



英语论文开题报告英语毕业论文写作指导英语论文写作笔记handbook英语论文提纲英语论文参考文献英语论文文献综述Research Proposal代写留学论文代写留学作业代写Essay论文英语摘要英语论文任务书英语论文格式专业名词turnitin抄袭检查









论文作者:www.51lunwen.org论文属性:短文 essay登出时间:2015-12-27编辑:dou1901点击率:4264

论文字数:717论文编号:org201511162313387186语种:英语 English地区:中国价格:免费论文

关键词:The future of drug therapy案例研究药物基因组学







The future of drug therapy

药物基因组学:未来药物治疗?-Pharmacogenomics: The future of drug therapy?

Drug treatment remains the Mainstay of medicine (this is quoted directly FIX). In certain situations a drug may have life threatening side effects where the patient may have an adverse reaction to the drug itself, or in dire cases where a patient's life is at stake and the drug unexpectedly has no effect. These situations are the reasons to why Pharmacogenomics was established and now offers insight into the aetiological mechanisms.

一个案例研究表示-A case study showed:

“A young pregnant women who underwent a sectio caesariae was given suxomethonium which normally acts as a muscle relaxant n the induction of anaesthesia, she was paralysed for 6 hours after the procedure, making it necessary to give her assisted ventilation by respirator. Blood tests revealed that she suffered from pseudocholinesterase (buturycholinesterase) deficiency” (Fagerlund and Braaten 2001).
Our case study exhibits that every person has a different genetic make-up and that The “one size fits all” Jesse J.swen et al. (2007) attitude towards drugs and dosages does not always suffice.
Clinical Pharmacogenomics assures this idea of personalised medicine consequently decreasing adverse drug reactions and increasing the safety and efficacy of drug prescription. A recent study (Hess and Cooper 1999) indicated that most variable drug responsiveness is caused by mutations in the genome known as polymorphisms.
The most common mutations found causing genetic variation are known as single nucleotide polymorphisms (SNPs) where there's a single switch in the nucleotide bases; substitution, deletion or insertion. A recent study (SL et al. 2000) indicated that these polymorphisms are to be accountable for 90% of all inter-individual variation. A polymorphic gene can have tragic consequences for a person as a change in the nucleotide sequence of a gene alters the mRNA strand which transfers the DNA sequence for the coding of an amino acid and if the correct amino acid is not produced it ultimately leads to the wrong protein being produced. This variation can therefore affect drug safety and efficacy if a protein that is normally a drug target or involved in the drug transport is altered.(Veenstra and Higashi 2000).
Metabolising enzymes are another cause to explore as variations in these genes can result in array of different phenotypes. One important family of enzyme metabolisers are the “cytochrome P450” and account for most of phase 1 metabolism of drugs, in studying this family it gives an insight into some of the causes of adverse drug reactions and steps to take in order to prevent thes论文英语论文网提供整理,提供论文代写英语论文代写代写论文代写英语论文代写留学生论文代写英文论文留学生论文代写相关核心关键词搜索。

共 1/2 页首页上一页12下一页尾页


    英国英国 澳大利亚澳大利亚 美国美国 加拿大加拿大 新西兰新西兰 新加坡新加坡 香港香港 日本日本 韩国韩国 法国法国 德国德国 爱尔兰爱尔兰 瑞士瑞士 荷兰荷兰 俄罗斯俄罗斯 西班牙西班牙 马来西亚马来西亚 南非南非