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The significance and progress of the Microbial genomics

1. Introduction

Recently, the research about pathogenic microorganisms genome have a rapid progress. The so-called genome research means that sequencing all the genes of the microorganism nucleotide, and researching the function of the single gene or genes interaction on the basis of understanding the structure of the genes. In the past, people just analysis microorganisms from. The phenotype, so they knows only small number of microorganisms genes actually such as the streptokinase g code gene of Streptococcus and the heat shock protein code gene Tuberculosis Bacili etc. Therefore, there still a large number of unknown genes have not been found. Through the genome research, it could reveal all the genes of microorganisms. It not only can discover new genes but also discover the interaction between them, and the new regulation factor etc. That research will make human master the athogenic mechanism of pathogenic microorganisms and its regular pattern, and to develop new method to diagnosis, prevention and vaccine or pharmaceutical preparations to against microbial infection from the high-level. Moreover, new discovered microbial enzymes and proteins may have some agricultural and industrial values. As the Institute for Genomic Research reported, human has finished many human diseases related Microbial genome sequencing such as Haemophilus influenzae, and Staphylococcal aureus, Mycoplasma genitalium, Mycoplasma pneumonia, Helicobacter pylori, Bacillus subtilis, Borrelia burgdorferi, Mycobacterium tuberculosis, Treponema pallidum, Chlamydia trachomatis, Rickettsia prowazeki and so on. [1]

2. The progress of Viral genome researching

3. The progress of Bacterial genome researching

4.0 Conclusion

Reference　
1. Fraser CM, Norrie SJ, Weinstock, et al,1998, “Complete genome sequence of Treponema Pallidum,the syphilis spirochete”. Science, 182∶375-388.

2. Von Regenmortel MHV, 1998, “Emphasis shifting from genomics to virus-host interactions”. ASM News, 64∶683-687.

3. Loman NJ, Snyder LA, Linton JD, Langdon R, Lawson AJ, Weinstock GM, Wren BW, Pallen MJ. J., 2009, “Genome sequence of the emerging pathogen Helicobacter Bacteriol”. J Bacteriol, Sep;191(17):5566-7. Epub 2009 Jun 19. https://www.51lunwen.org/mgzuoye/2012/0617/2133309017.html

4. Alm RA, Ling LS, Heir DT,et al. 1999, ”Genomic-sequence -comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori”. Nature, 397∶176-180.

5.Cohen ST,Brosch R, Parkhill J, et al. 1998, ”Deciphering the biology of Mycobacterium Tuberculosis from the complete sequence”. Nature, 393∶537-544.